Applications in Research
HealthMeasures can be used in clinical research settings, including clinical trials, observational studies, and comparative effectiveness research.
HealthMeasures in Drug Development
- HealthMeasures can be used as primary or secondary endpoints in clinical and observational studies on the effectiveness of treatment.
- HealthMeasures, particularly PROMIS, can measure symptomatic adverse events, physical function, and disease-related symptoms (e.g., dyspnea) as recommended for cancer clinical trials. Learn more>>
- Researchers and sponsors should review the evidence to support the context of use.
- Efforts are underway to seek qualification for PROMIS measures.
- The FDA’s Clinical Outcomes Assessment (COA) Compendium includes the PROMIS® Physical Function measures for assessing physical function in sarcopenia and oncology.
- For publications and webinars on assessment of patient-reported outcomes (PROs) in children and adolescents, content validity in PRO instruments and good practices for outcomes research visit the website of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR).
Evidence Supporting the Validity of HealthMeasures
HealthMeasures have substantial qualitative and quantitative evidence for their validity in a range of populations and for different purposes. Read more about validity for
Patient-Centered Outcomes Research Institute (PCORI) acknowledges the importance of the PROMIS initiative with extensive funding opportunities
Since its first funding announcement in 2012, PCORI has awarded nearly $27 million to studies using PROMIS measures. In addition to a PROMIS-specific funding announcement in 2014 totaling $5 million in support, PCORI continues to recognize the importance of PROMIS by soliciting input on the future involvement of PROMIS’ methodology and measures within its research portfolio.
Results of the inaugural pilot studies featuring PROMIS measures are now available at www.pcori.org.